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位置: 首页 > 磷酸化抗体 > Tau(Phospho-Ser262) Antibody

Tau(Phospho-Ser262) Antibody#11111

Tau(Phospho-Ser262) Antibody
Tau(Phospho-Ser262) Antibody
Tau(Phospho-Ser262) Antibody
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产品总价:
产品详情

产品名称Tau(Phospho-Ser262) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB,ELISA

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of Tau only when phosphorylated at serine 262.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 262 (I-G-S(p)-T-E) derived from Human Tau.

基因/蛋白名称Tau

修饰Phospho

别名MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau

数据库入口号Swiss-Prot: P10636
NCBI Protein: NP_001116538.1

UniprotP10636

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 48 62 78 kd
Western blotting: 1:500~1:1000

Western blot analysis of extracts from mouse brain tissue using Tau(Phospho-Ser262) Antibody #11111 and the same antibody preincubated with blocking peptide.
Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer
Immunofluorescence staining of methanol-fixed Hela cells using Tau(Phospho-Ser262) Antibody #11111.
背景

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Timm T, et al. (2003) EMBO J; 22(19): 5090-5101.

如果您使用该产品11111发表了文章,请通知我们,让我们可以引用您的文献。

et al,Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer's disease-like neuropathology and cognitive deficitsInAging (Albany NY)On2023 Dec 12byLing Lei?1?2,?Yong Luo et al..PMID:?38095632, , (2023),
PMID: 38095632
et al,INVESTIGATING THE DNA DAMAGE RESPONSE IN, , (2023),
PMID:
et al,HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia. In Int J Mol Sci on 2022 Dec 17 by Ling Lei, Jun Feng,et al..PMID:36555780, , (2022),
PMID: 36555780
et al,A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. In Theranostics on 2021 Mar 11 by Weijin Wang, Qiuzhi Zhou, et al..PMID:33859747, , (2021),
PMID: 33859747
et al,14-3-3ζ Captures SET in the Cytoplasm, Mediating Tau Pathology and Cognitive Impairments., , (2021),
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et al,FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro. In Neurosci Lett on 2020 Nov 1 by Wei Zhang, Shanshan Bai,et al..PMID:32860886, , (2020),
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et al,Trillium tschonoskii maxim extract attenuates abnormal Tau phosphorylation.Neural Regen Res.In Neural Regen Res.On 2018 May by Luo HB, Shang N. et al..PMID: 29863023, , (2018),
PMID: 29863023
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et al,Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation .In Neurosci Bull. On 2018 Apr by Wei YP, Ye JW et al..PMID: 28646348, , (2018),
PMID: 28646348
et al,Extrasynaptic NMDA Receptor-Induced Tau Overexpression Mediates Neuronal Death Through Suppressing Survival Signaling ERK Phosphorylation.In Cell Death Dis on 2016 Nov 3 by Xu-Ying Sun , Qing-Zhang Tuo et al..PMID: 27809304, , (2016),
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et al,Zinc binds to and directly inhibits protein phosphatase 2A in vitro.In Neurosci Bull.On 2015 Jun by Xiong Y, Luo DJ et al..PMID:25854679 , , (2015),
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et al,A novel mechanism of spine damages in stroke via DAPK1 and tau.In Cereb Cortex on 2015 Nov by Lei Pei, Shan Wang et al..PMID: 25995053 , , (2015),
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et al,Extra-virgin olive oil attenuates amyloid-尾 and tau pathologies in the brains of TgSwDI mice. In J Nutr Biochem on 2015 Dec by Hisham Qosa, Loqman A Mohamed,et al..PMID:26344778, , (2015),
PMID: 26344778
et al,Hyperphosphorylation and cleavage at D421 enhance tau secretion. In PLoS One on 2012 by Vanessa Plouffe, Nguyen-Vi Mohamed, et al..PMID: 22615831, , (2012),
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et al,The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons. In Neuroscience on 2010 Jun 30 by J Bertrand, V Plouffe, et al..PMID: 20394726, , (2010),
PMID: 20394726
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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